The present randomised double blind studied the short-term effect of sucralose consumption on metabolic response and gut microbiome among 34 healthy men between the age of 18 to 50 years and BMI of 20 to 30 kg/m2. It concluded consumption of high doses of sucralose for 7 days in healthy adults does not alter glycaemic control or insulin sensitivity. There was no change in gut microbiome after consumption of sucralose or placebo.
Fasting plasma glucose and fasting serum insulin concentrations remained unaffected by the daily consumption of sucralose at high dose equivalent to the 75% of the Acceptable Daily Intake for sucralose (15 mg/kg/d) in the intervention group. Between intervention and placebo group, insulin sensitivity markers showed no difference. Also high dose of sucralose consumption for 7 days had no impact on the gut microbiota as microbiome composition was not affected by the intervention.
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