Clinical Summary
The use of Low-calories sweeteners (LCS) in energy-restricted diets is often questioned about their possible effects on driving the consumption of more sweet-tasting foods. Prolonged exposure to low-calories and non-calorie sweeteners has been frequently accused of the possibility of initiating and enhancing the craving for ‘Sweetness’. The current article presents the clinical findings from observational studies, experimental laboratory studies, RCTs as well as functional MRI studies that detail the effect of these sweeteners on the urge to consume sweet foods.
It has been observed, that the use of LCS does not have any consistent association with increasing the appetite for sugar or sweet products. The interventional studies had similar conclusions on various consumers – male and female – regardless of their body weight. In fact, the use of LCS in many instances lowered the consumption of these food products that could possibly help in weight control and management. The direct effects of the sweeteners require to be evaluated of their effect on weight loss, weight-gain prevention and maintenance, through long-term RCTs.
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